Title:increased Expression of the Homeostatic Chemokines Ccl19 and Ccl21 in Clinical and Experimental Rickettsia Conorii Infection
نویسندگان
چکیده
The study by Elisabeth Astrup examined the serum levels of CCL19 and CCL21 in patients with R. africae and R. conorii infection and in murine models of spotted fever rickettsiosis. The study is significant as it examines human immune responses to this important Rickettsial pathogen and confirms the results in suitable murine model. However, the study does not provide new information and the conclusion that these chemokines and CCR7 receptor play a pathogenic role in Rickettsia infection is not supported by the data.
منابع مشابه
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
BACKGROUND Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. METHODS Serum levels of CCL19 and CCL21 in patients with R. africae and R. conorii infection were analyzed by enzyme immunoassays. Lungs from R. conorii infected mice were examined f...
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